clinical-trial
openbooklet.com/s/clinical-trialopenbooklet.com/s/clinical-trial@1.0.0GET /api/v1/skills/clinical-trialDesigns and analyzes clinical trials including sample size calculation, randomization schemes, endpoint selection, CONSORT reporting, and interim analysis planning; trigger when users ask about RCTs, Phase I-IV trials, or clinical study design.
Analyzes astronomical observations and cosmological models including telescope data processing, celestial mechanics calculations, stellar evolution, galaxy classification, and cosmological parameter estimation; trigger when users discuss stars, galaxies, exoplanets, dark matter, or the universe's large-scale structure.
Bioinformatics operations via Biopython. Use when: user asks about DNA/protein sequences, BLAST, or PDB structures. NOT for: clinical genomics or variant calling pipelines.
US Census Bureau data via API. Use when: user asks about US demographics, population, housing, or economic data by geography. NOT for: non-US data or real-time statistics.
Query the ChEMBL REST API for drug-target interactions, bioactivity data, ADMET properties, and approved drug information. Use when the user needs drug mechanism of action, binding affinity data, target information, or pharmacokinetic properties. NOT for basic compound lookup (use pubchem-compound), NOT for gene-disease associations (use open-targets), NOT for protein 3D structures (use pdb-structure).
Computational chemistry tools including molecular structure, chemical reactions, thermodynamics, spectroscopy analysis, and cheminformatics. Use when user works with chemical formulas, molecular structures, reaction balancing, thermodynamic calculations, or chemical databases (PubChem, ChemSpider). Triggers on "chemical structure", "molecular weight", "balance equation", "reaction", "thermodynamics", "spectroscopy", "SMILES", "PubChem", "chemical formula", "stoichiometry".
Scientific programming best practices including reproducible research, computational notebooks, version control for research, data management, HPC/parallel computing, and research software engineering. Use when user needs help with research code organization, reproducibility, scientific Python/R workflows, or computational infrastructure. Triggers on "reproducible research", "research code", "scientific computing", "HPC", "parallel computing", "Jupyter", "notebook", "data management plan", "research software", "code review for science".
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Access Copernicus Climate Data Store (CDS) for ERA5 reanalysis, climate projections, and satellite observations. Use when: (1) retrieving historical weather/climate data, (2) downloading ERA5 reanalysis fields, (3) querying climate projections (CMIP), (4) getting satellite-derived climate variables. NOT for: real-time weather forecasts (use weather APIs), ocean biology (use Copernicus Marine), air quality (use CAMS).
Academic metadata search via CrossRef API. Use when: user needs DOI resolution, citation counts, journal metadata, or publisher info. NOT for: full-text access or downloading papers.
Perform statistical tests, hypothesis testing, correlation analysis, and multiple testing corrections using scipy and statsmodels. Works with ANY LLM provider (GPT, Gemini, Claude, etc.).
Transform, clean, reshape, and preprocess data using pandas and numpy. Works with ANY LLM provider (GPT, Gemini, Claude, etc.).
Create publication-quality plots and visualizations using matplotlib and seaborn. Works with ANY LLM provider (GPT, Gemini, Claude, etc.).
Computer science bibliography via DBLP API. Use when: user asks about CS publications, author publication lists, or venue (conference/journal) metadata. NOT for: non-CS publications or citation counts.
COPYRIGHT NOTICE
Supports drug discovery workflows including target identification, virtual screening, ADMET prediction, lead optimization, pharmacokinetics modeling, and drug repurposing analyses; trigger when users discuss drug targets, compound libraries, medicinal chemistry, or pharmaceutical development.
Orchestrates a full drug discovery workflow from target identification through lead optimization. Use when searching for drug candidates against a biological target, evaluating compound libraries, or optimizing hits for drug-likeness. NOT for pure protein structure analysis or single-compound lookups.
Analyzes energy systems including renewable energy resource assessment, power grid modeling, battery storage optimization, energy efficiency evaluation, and techno-economic analysis of energy technologies; trigger when users discuss solar, wind, grid integration, energy storage, or power system design.
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